©2019 by London Biofoundry.

January 2019

Suckling L, McFarlane C, Sawyer C, Chambers SP, Kitney RI, McClymont DW,
Freemont PS.  Synth Syst Biotechnol. 2019 Jan 22;4(1):57-66. doi: 10.1016/j.synbio.2019.01.002.

eCollection 2019 Mar. PubMed PMID: 30723818; PubMed Central PMCID: PMC6352296.

January 2019

Utilising datasheets for the informed automated design and build of a
synthetic metabolic pathway.

May 2018

Exley K, Reynolds CR, Suckling L, Chee SM, Tsipa A, Freemont PS, McClymont D,
Kitney RI. J Biol Eng. 2019 Jan 18;13:8. doi:10.1186/s13036-019-0141-z. eCollection 2019. PubMed PMID: 30675181; PubMed Central PMCID: PMC6339355.


 

Rapid acquisition and model-based analysis of cell-free transcription-translation reactions from nonmodel bacteria.

 Moore SJ, MacDonald JT, Wienecke S, Ishwarbhai A, Tsipa A, Aw R, Kylilis N, Bell DJ, McClymont DW, Jensen K, Polizzi KM, Biedendieck R, Freemont PS. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4340-E4349. doi: 10.1073/pnas.1715806115. Epub 2018 Apr 17. PubMed PMID: 29666238; PubMed Central PMCID: PMC5948957.

December 2017

A Cell-Free Biosensor for Detecting Quorum Sensing Molecules in P. aeruginosa-Infected Respiratory Samples.

Wen KY, Cameron L, Chappell J, Jensen K, Bell DJ, Kelwick R, Kopniczky M, Davies JC, Filloux A, Freemont PS. CS Synth Biol. 2017 Dec 15;6(12):2293-2301. doi: 10.1021/acssynbio.7b00219. Epub 2017 Oct 5.
PubMed PMID: 28981256.


 

April 2017

With all due respect to Maholo, lab automation isn't anthropomorphic.

McClymont DW, Freemont PS. Nat Biotechnol. 2017 Apr 11;35(4):312-314. doi:
10.1038/nbt.3795. PubMed PMID: 28398331.

May 2017

Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker's yeast.

 Awan AR, Blount BA, Bell DJ, Shaw WM, Ho JCH, McKiernan RM, Ellis T. Nat Commun. 2017 May 4;8:15202. doi: 10.1038/ncomms15202. PubMed PMID: 28469278;
PubMed Central PMCID: PMC5418595.

October 2016

EcoFlex: A Multifunctional MoClo Kit for E. coli Synthetic Biology.

Moore SJ, Lai HE, Kelwick RJ, Chee SM, Bell DJ, Polizzi KM, Freemont PS. ACS Synth Biol. 2016 Oct 21;5(10):1059-1069. Epub 2016 May 2. PubMed PMID: 27096716.

Our Published Work

May 2019

Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS.

Nat Commun. 2019 May 9;10(1):2040. doi: 10.1038/s41467-019-10079-2. No abstract available.

April 2019

Engineering a Model Cell for Rational Tuning of GPCR Signaling.

Shaw WM, Yamauchi H, Mead J, Gowers GF, Bell DJ, Öling D, Larsson N, Wigglesworth M, Ladds G, Ellis T.  Cell. 2019 Apr 18;177(3):782-796.e27. doi:10.1016/j.cell.2019.02.023. Epub 2019 Apr 4. PubMed PMID: 30955892; PubMed Central PMCID: PMC6476273.

April 2019

Enabling the Advanced Bioeconomy through Public Policy Supporting Biofoundries and Engineering Biology.

Kitney R, Adeogun M, Fujishima Y, Goñi-Moreno Á, Johnson R, Maxon M, Steedman S, Ward S, Winickoff D, Philp J. Trends Biotechnol. 2019 Apr 26. pii: S0167-7799(19)30076-9. doi: 10.1016/j.tibtech.2019.03.017. [Epubahead of print] PubMed PMID: 31036350.

January 2019

Miniaturisation of high-throughput plasmid DNA library preparation
for next-generation sequencing using multifactorial optimisation.

Suckling L, McFarlane C, Sawyer C, Chambers SP, Kitney RI, McClymont DW,
Freemont PS.  Synth Syst Biotechnol. 2019 Jan 22;4(1):57-66. doi: 10.1016/j.synbio.2019.01.002.

eCollection 2019 Mar. PubMed PMID: 30723818; PubMed Central PMCID: PMC6352296.

January 2019

Utilising datasheets for the informed automated design and build of a
synthetic metabolic pathway.

May 2018

Exley K, Reynolds CR, Suckling L, Chee SM, Tsipa A, Freemont PS, McClymont D,
Kitney RI. J Biol Eng. 2019 Jan 18;13:8. doi:10.1186/s13036-019-0141-z. eCollection 2019. PubMed PMID: 30675181; PubMed Central PMCID: PMC6339355.


 

Rapid acquisition and model-based analysis of cell-free transcription-translation reactions from nonmodel bacteria.

 Moore SJ, MacDonald JT, Wienecke S, Ishwarbhai A, Tsipa A, Aw R, Kylilis N, Bell DJ, McClymont DW, Jensen K, Polizzi KM, Biedendieck R, Freemont PS. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4340-E4349. doi: 10.1073/pnas.1715806115. Epub 2018 Apr 17. PubMed PMID: 29666238; PubMed Central PMCID: PMC5948957.

December 2017

A Cell-Free Biosensor for Detecting Quorum Sensing Molecules in P. aeruginosa-Infected Respiratory Samples.

May 2017

Wen KY, Cameron L, Chappell J, Jensen K, Bell DJ, Kelwick R, Kopniczky M, Davies JC, Filloux A, Freemont PS. CS Synth Biol. 2017 Dec 15;6(12):2293-2301. doi: 10.1021/acssynbio.7b00219. Epub 2017 Oct 5.
PubMed PMID: 28981256.


 

Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker's yeast.

 Awan AR, Blount BA, Bell DJ, Shaw WM, Ho JCH, McKiernan RM, Ellis T. Nat Commun. 2017 May 4;8:15202. doi: 10.1038/ncomms15202. PubMed PMID: 28469278;
PubMed Central PMCID: PMC5418595.

April 2017

With all due respect to Maholo, lab automation isn't anthropomorphic.

McClymont DW, Freemont PS. Nat Biotechnol. 2017 Apr 11;35(4):312-314. doi:
10.1038/nbt.3795. PubMed PMID: 28398331.

April 2017

Streptomyces venezuelae TX-TL - a next generation cell-free synthetic biology tool.

Moore SJ, Lai HE, Needham H, Polizzi KM, Freemont PS. Biotechnol J. 2017 Apr;12(4). doi: 10.1002/biot.201600678. Epub 2017 Feb 24. PubMed PMID: 28139884.

November 2016

Development of a Bacillus subtilis cell-free transcription-translation system for prototyping regulatory elements.

Kelwick R, Webb AJ, MacDonald JT, Freemont PS. Metab Eng. 2016 Nov;38:370-381. doi: 10.1016/j.ymben.2016.09.008. Epub 2016 Sep 30. PubMed PMID: 27697563.

October 2016

EcoFlex: A Multifunctional MoClo Kit for E. coli Synthetic Biology.

Moore SJ, Lai HE, Kelwick RJ, Chee SM, Bell DJ, Polizzi KM, Freemont PS. ACS Synth Biol. 2016 Oct 21;5(10):1059-1069. Epub 2016 May 2. PubMed PMID: 27096716.